The aim of this research was to design a framework for integrating e-learning in Higher Education Institutions in developing countries. Data were collected from 266 university students and staff of five universities in Uganda using a questionnaire and analyzed. In addition, different e-learning frameworks and models were studied and used as benchmarks for purposes of designing the proposed framework. The applicability of the proposed framework was validated with case studies in all the participating universities. Validation results indicate that the proposed framework, if well implemented can help improve e-learning integration in Higher Education Institutions operating in developing countries since it provides a step by step approach to be used during e-learning integration and also identifies the key stakeholders and their roles for successful e-learning integration.